In a double stranded DNA adenine always pairs with thymidine & guanine always pairs with cytosine.so knowing the base pairs in strand we can determine the base pairs of the other strand.Cal R immunohistochemistry and bromo-deoxyuridine birthdating confirmed the abnormality in position of the earliest generated cortical cells of mutants.These observations suggest that the p35/Cdk5 pathway plays a role in preplate splitting in addition to regulating layer formation.hence DNA strand acts as a template during DNA replication.Denise O'Toole has written: 'Isolation and southern blot characterisation of ethyl methanesulphonate-induced mutants at the aprt locus of wild-type and thymidine kinase deficient friend erythroleukaemia cells' DPD is the rate limiting enzyme involved in the catabolism of pyrimidines like thymidine and uracil.
the 4 nucleotide bases are adenine, guanine, thymidine & cytosine.
Our data demonstrated changes in early cortical lamination and aberrant thalamic axon trajectories in these mice.
Specifically, LI was thicker, and cell-dense and thalamic axons did not accumulate in the SP layer before invading the CP.
DPD is also the main enzyme involved in the degradation of structurally related compounds like 5-Fluorouracil (5-FU), a widely used anticancer drug.
According to Stedman's Medical Dictionary (Copyright © 2006 Lippincott Williams and Wilkins), azidothymidine (AZT) is a thymidine analog that is an inhibitor of in vitro replication of HIV virus, the causative agent of AIDS and ARC, and is used in the management of these diseases.