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(16) Divergence from the normal number of X and Y chromosomes, called sex chromosome aneuploidy (SCA), accounts for approximately half of all chromosomal anomalies in humans with a total frequency of 0.

(17) Sex chromosome physical abnormalities are able to be diagnosed prenatally via amniocentesis and chorionic villi sampling (CVS).

Such a discrepancy is highlighted by the existence of intersex individuals whose psychosexual development and gender sometimes do not match the biological sex assigned to them as infants.

In this report the term ‘sex’ will be used where the practice refers to biological sex and not the more social construct of ‘gender’.

(5) When a Y chromosome is present, early embryonic testes develop around the 10th week of pregnancy.

These include mutations or structural anomalies of the SRY region on the Y chromosome resulting in XY gonadal dysgenesis, XX males, or XY females; defects of androgen biosynthesis or androgen receptors, and others. Research suggests, however, that in a few births per thousand some individuals will be born with a single sex chromosome (45X or 45Y) (sex monosomies) and some with three or more sex chromosomes (47XXX, 47XYY or 47XXY, etc.) (sex polysomies).Clearly, there are not only females who are XX and males who are XY, but rather, there is a range of chromosome complements, hormone balances, and phenotypic variations that determine sex.(15)Aneuploidy is the condition of having less than (monosomy) or more than (polysomy) the normal diploid number of chromosomes.Aneuploidy occurs in at least 5% of all pregnancies and is the most commonly recognized chromosome abnormality in humans.

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